The SCSB Cryo EM laboratory (Cryo EM Core), located on the first floor of the Medical Research Building, has laboratory space featuring a BSL-3 room for viral and pathogen work. In addition the laboratory has an open research space where structure of macromolecules, their complexes, cell organelles, and other biological systems can be studied using various EM techniques including cryo-electron microscopy and (cryo-)electron tomography. The Laboratory has three modern JEOL cryo-electron microscopes with a state-of-the-art 200 keV JEOL 2200FS cryo EM with in-column electron energy filter and field emission gun, the brightest available today electron source, a 200 keV JEOL 2100 EM, and a 120 keV JEM1400 microscope.
The high-resolution JEM2200FS (left) is located in the W.M. Keck Center for virus imaging BSL-3 containment area which permits the safe structural imaging of highly infectious pathogens that could not studied in the open research area. This is the first cryo-EM facility in the U.S. designed for high-resolution structural studies of wild type infectious agents. The microscope can be controlled remotely through a computer network, which provides for remote online users and largely extends our user base.
The JEM2100 (right) is available for imaging of non-pathogenic targets. A 120 keV JEM1400 microscope is available for imaging of negatively stained samples, thin, and semi-thick plastic cell- and tissue sections and electron tomography of these samples. It is used for user training as well as for imaging and structural studies. A shared Crystallographic/EM Computational Lab provides high-throughput image-processing with a dedicated 120-core EM Image-Processing Cluster. Images are stored in a local EMEN database that is archived remotely.

Microscope scheduling for qualified users is available online.